To allow for certain significant changes to be preapproved by the Institutional Animal Care and Use Committee (IACUC) and verified by a research veterinarian. This policy will facilitate and speed protocol revisions, improve compliance, and reduce the regulatory burden on UW–Madison principal investigators (PIs).
In August 2014, the Office of Laboratory Animal Welfare (OLAW) provided new guidance on significant changes to animal activities (NOT-OD-14-126) in an effort to support the use of performance standards and professional judgment and to reduce regulatory burden.
At UW–Madison, the following significant changes to an IACUC protocol may be handled administratively without review by the full committee or designated member review.
Only the UW– Madison chief campus veterinarian or delegates (see attached list) may administratively verify changes through veterinary verification and consultation (VVC) if changes are consistent with policies (guidance documents, standard operating procedures, and formularies) previously approved by the IACUCs. These changes may include:
The significant changes described above may be handled administratively according to IACUC-reviewed and -approved policies in consultation with a veterinarian authorized by the IACUC. The veterinarian is not conducting DMR but is serving as a subject matter expert to verify that compliance with the IACUC-reviewed and -approved policy is appropriate for the animals in this circumstance.
Consultation with the veterinarian must occur before any change in work is started and must be documented. A list of changes administratively handled by VVC will be provided to the IACUC at least quarterly. The veterinarian may refer any request to the IACUC for review for any reason and must refer any request that does not meet the parameters of the IACUC-reviewed and -approved policies. The following significant changes may not be handled administratively by VVC and must undergo either a full committee or designated member review:
See companion VVC Standard Operating Procedures (SOPs) for specific examples and a list of guidance documents, SOPs, and formularies currently approved by the IACUCs for VVC.